• Medicina clinica · Mar 2022

    Prognostic implications of hypo and hyperkalaemia in acute heart failure with reduced ejection fraction. Analysis of cardiovascular mortality and hospital readmissions.

    • Rocío Del Pilar Laymito-Quispe, Raquel López-Vilella, Ignacio Sánchez-Lázaro, Víctor Donoso-Trenado, Silvia Lozano-Edo, Luis Martínez-Dolz, and Luis Almenar-Bonet.
    • Unidad de Insuficiencia Cardíaca y Trasplante, Hospital Universitari i Politècnic La Fe, Valencia, España; Servicio de Cardiología, Hospital Universitari i Politècnic La Fe. Valencia, España. Electronic address: chiolaymito@yahoo.es.
    • Med Clin (Barc). 2022 Mar 11; 158 (5): 211-217.

    Background And ObjectivesPotassium alterations constitute a major clinical problem in decompensated heart failure (HF). This study aims to assess the prognostic implications of hypo and hyperkalaemia on admission for acute HF in cardiovascular mortality and hospital readmissions.Material And MethodFrom January 2016 to June 2020, 1,397 cases with a diagnosis of acute HF were admitted. Admission programmed for study, elective therapies, and patients with LVEF> 40% were excluded. The study was carried out on 689 patients, 45 with K+ <3.5 mmol/L, 49K +>5.0 mmol/L and 595K+3.5-5.0 mmol/L. Medical history, baseline clinical profile, drug therapy, and potassium levels obtained upon admission were analysed.ResultsAnnual mortality due to hypokalaemia (K+<3.5mmol/L) was 37.8% (HR 2.4; 95% CI: 1.3-4.7; P<.007); for hyperkalaemia 40.8% (HR: 1.9; 95% CI: 0.98-3.51; P<.055). Creatinine level and age were variables associated with mortality in both the hyperkalaemic and hypokalaemic cohorts. Hospital readmissions did not show statistical association with these electrolyte disorders.ConclusionsIn patients admitted for decompensated HF, both hyperkalaemia and hypokalaemia determined at admission have a negative prognostic impact on survival. Creatinine and age are other independent factors associated with mortality. The effect on the probability of hospital readmission at one year is not demonstrated in this study.Copyright © 2021 Elsevier España, S.L.U. All rights reserved.

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