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- Paul Baron, Roel Deckers, Martijn de Greef, Laura G Merckel, Chris J G Bakker, Job G Bouwman, Ronald L A W Bleys, Maurice A A J van den Bosch, and Lambertus W Bartels.
- Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
- Magn Reson Med. 2014 Dec 1; 72 (6): 1580-9.
PurposeIn this study, we aim to demonstrate the sensitivity of proton resonance frequency shift (PRFS) -based thermometry to heat-induced magnetic susceptibility changes and to present and evaluate a model-based correction procedure.Theory And MethodsTo demonstrate the expected temperature effect, field disturbances during high intensity focused ultrasound sonications were monitored in breast fat samples with a three-dimensional (3D) gradient echo sequence. To evaluate the correction procedure, the interface of tissue-mimicking ethylene glycol gel and fat was sonicated. During sonication, the temperature was monitored with a 2D dual flip angle multi-echo gradient echo sequence, allowing for PRFS-based relative and referenced temperature measurements in the gel and T1 -based temperature measurements in fat. The PRFS-based measurement in the gel was corrected by minimizing the discrepancy between the observed 2D temperature profile and the profile predicted by a 3D thermal model.ResultsThe HIFU sonications of breast fat resulted in a magnetic field disturbance which completely disappeared after cooling. For the correction method, the 5th to 95th percentile interval of the PRFS-thermometry error in the gel decreased from 3.8°C before correction to 2.0-2.3°C after correction.ConclusionThis study has shown the effects of magnetic susceptibility changes induced by heating of breast fatty tissue samples. The resultant errors can be reduced by the use of a model-based correction procedure.© 2013 Wiley Periodicals, Inc.
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