• Kenji Kuroda, Akio Horiguchi, Takako Asano, Shinsuke Tasaki, Hidehiko Yoshii, Akinori Sato, Junichi Asakuma, Keiichi Ito, Kenji Seguchi, Makoto Sumitomo, and Tomohiko Asano.
• Department of Urology, National Defense Medical College, Tokorozawa, Japan. kksmy @ sa2.so-net.ne.jp
• Urol. Int. 2012 Jan 1; 88 (1): 18-24.

IntroductionLymphatic invasion has been associated with biochemical recurrence (BCR), and many patients with postoperative elevation of prostate-specific antigen (PSA) develop distant metastases within several years. We previously found peritumoral lymphatic vessel density (PTLD) in biopsy cores to be an independent predictor of lymphatic invasion in radical prostatectomy specimens, so we speculate that PTLD parameters in biopsy specimens could also be independent predictors of BCR after surgery.Patients And MethodsWe obtained positive biopsy cores from 110 patients who underwent radical prostatectomy at our institution. Biopsy cores were immunostained with the D2-40 monoclonal antibody, which specifically and selectively detects lymphatic endothelium. We evaluated differences between the BCR-free survival rates and used univariate and multivariate analyses to detect independent predictors of BCR.ResultsThe results of a Cox proportional hazards model showed that lymphatic invasion in prostatectomy specimens was one of the independent postoperative prognostic factors for BCR (p = 0.0338). An additional model showed that one PTLD parameter, maximal PTLD, was among the independent preoperative predictors of lower BCR-free survival rates (p = 0.0200).ConclusionsInformation about PTLD in prostate biopsy specimens could be helpful for selecting patients as radical prostatectomy candidates, and patients with high PTLD values should be carefully monitored after surgery.Copyright © 2012 S. Karger AG, Basel.

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