• Albert P Chen, Charles H Cunningham, Esin Ozturk-Isik, Duan Xu, Ralph E Hurd, Douglas A C Kelley, John M Pauly, John Kurhanewicz, Sarah J Nelson, and Daniel B Vigneron.
• Department of Radiology, University of California at San Francisco, San Francisco, CA 94143, USA.
• J Magn Reson Imaging. 2007 Jun 1; 25 (6): 1288-92.

AbstractProstate MR spectroscopic imaging (MRSI) at 3T may provide two-fold higher spatial resolution over 1.5T, but this can result in longer acquisition times to cover the entire gland using conventional phase-encoding. In this study, flyback echo-planar readout trajectories were incorporated into a Malcolm Levitt's composite-pulse decoupling sequence (MLEV)-point-resolved spectroscopy sequence (PRESS) to accelerate the acquisition of large array (16 x 16 x 8), high spatial (0.154 cm(3)) resolution MRSI data by eight-fold to just 8.5 minutes. Artifact free, high-quality MRSI data was obtained in nine prostate cancer patients. Easy data reconstruction and the robustness of the flyback echo-planar encoding make this technique particularly suitable for the clinical setting. The short acquisition time provided by this method reduces the 3T prostate MRI/MRSI exam time, allows longer repetition times, and/or allows the acquisition of additional MR acquisitions within the same exam.(c) 2007 Wiley-Liss, Inc.

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