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Microbes and infection · Oct 2020
EditorialOut of the frying pan and into the fire? Due diligence warranted for ADE in COVID-19.
- Jeremia M Coish and Adam J MacNeil.
- Department of Health Sciences, Faculty of Applied Health Sciences, Brock University, St. Catharines, Ontario, L2S 3A1, Canada. Electronic address: jc11yv@brocku.ca.
- Microbes Infect. 2020 Oct 1; 22 (9): 405-406.
AbstractAntibody-dependent enhancement (ADE) is an atypical immunological paradox commonly associated with dengue virus re-infection. However, various research models have demonstrated this phenomenon with other viral families, including Coronaviridae. Recently, ADE in SARS-CoV-2 has emerged as one hypothesis to explain severe clinical manifestations. Whether SARS-CoV-2 is augmented by ADE remains undetermined and has therefore garnered criticism for the improper attribution of the phenomenon to the pandemic. Thus, critical evaluation of ADE in SARS-CoV-2 vaccine development will be indispensable to avoid a global setback and the erosion of public trust.Copyright © 2020 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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