• Monika Gloor, Susanne Fasler, Arne Fischmann, Tanja Haas, Oliver Bieri, Karl Heinimann, Stephan G Wetzel, Klaus Scheffler, and Dirk Fischer.
• Division of Radiological Physics, Institute of Radiology, University of Basel Hospital, Basel, Switzerland. monika.gloor@unibas.ch
• J Magn Reson Imaging. 2011 Jan 1; 33 (1): 203-10.

PurposeTo analyze and compare three quantitative MRI methods to determine the degree of muscle involvement in oculopharyngeal muscular dystrophy (OPMD).Materials And MethodsMuscle fat content (MFC) was determined based on water-fat quantification using a 2-point Dixon (2PD) method and on a histogram analysis of the free induction decay (FID) signal of a gradient-spoiled steady-state free precession (SSFP) sequence. In addition, transverse relaxation times (T₂) of muscle tissue were calculated using a monoexponential decay model.ResultsWe observed an increased mean MFC in OPMD patients as compared to healthy controls with the adductor magnus and soleus muscles being the most involved muscles in the thigh and calf, respectively. Furthermore, strong correlations (0.78 < R² < 0.94) between different quantitative MR methods were observed. Fewer outliers, however, were obtained by the 2PD method and T₂ measurements, suggesting these methods being superior to the SSFP-FID method.ConclusionQuantitative MR techniques, such as fast multiecho Dixon methods and T₂ imaging, can reliably differentiate between healthy and dystrophic muscles in OPMD, even if muscles are only marginally affected. Quantitative methods thus represent a promising tool that may be able to monitor more objectively the individual disease progression and treatment response in future clinical trials in muscular dystrophies.Copyright © 2010 Wiley-Liss, Inc.

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