• Beatrijs H Wokke, Clemens Bos, Monique Reijnierse, Carla S van Rijswijk, Holger Eggers, Andrew Webb, Jan J Verschuuren, and Hermien E Kan.
• Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands. b.h.a.wokke@lumc.nl
• J Magn Reson Imaging. 2013 Sep 1; 38 (3): 619-24.

PurposeTo compare different lipid multipeak spectral models to the single-peak model in Dixon-based fat-water separation and to evaluate differences between visually scored magnetic resonance (MR) images and quantitatively assessed fat fractions in muscle of Duchenne muscular dystrophy patients.Materials And MethodsT1-weighted and 3-point Dixon imaging of the upper and lower leg was performed in 13 Duchenne patients and six healthy controls. Three-, four-, and five-peak lipid spectrum models were compared to a single-peak model and to each other. T1-weighted images were visually scored by two radiologists and quantitative fat fractions were obtained from Dixon images.ResultsDifferences between the multipeak spectral models were minimal. The three-peak model was used for subsequent comparisons. Although there was high correlation between quantitative and visual scores, visual scores were consistently higher than quantitative values of the same muscles.ConclusionThere are minor differences between the various lipid spectral models in terms of quantifying fat fraction in a large number of skeletal muscles in the legs of Duchenne patients and healthy controls. Quantitative 3-point Dixon MRI is more precise and reliable than visual radiological methods for evaluation of fat fractions for potential longitudinal follow-up or therapy evaluation of Duchenne patients.Copyright © 2013 Wiley Periodicals, Inc., a Wiley company.

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