• Jacobus F A Jansen, M Eline Kooi, Alfons G H Kessels, Klaas Nicolay, and Walter H Backes.
• Department of Radiology, Maastricht University Hospital, Maastricht, The Netherlands. j.f.a.jansen@tue.nl
• Invest Radiol. 2007 Jun 1; 42 (6): 327-37.

ObjectivesThe reproducibility of quantitative cerebral T2 relaxometry, diffusion tensor imaging, and H magnetic resonance (MR) spectroscopic imaging was assessed on a clinical 3.0 T MR system.Materials And MethodsRepeated measurements in 10 healthy volunteers were used to establish the reproducibility of quantitative measures derived from different quantitative MR techniques, namely the T2 relaxation time, the apparent diffusion coefficient (ADC), the fractional anisotropy (FA), and metabolite concentrations of N-acetyl-aspartate (NAA), creatine (Cr), choline (Cho), and myo-inositol (mI). Results were compared with previously reported reproducibility measures from 1.5 T.ResultsThe coefficient of variation (CV) was < or =1.6% for T2, < or =1.6% for ADC, and < or =5.3%, for FA in the cerebrum. For metabolites the CV was < or =8.0% in the frontal lobe and < or =20.4% in the temporal lobe.ConclusionsThe reproducibility of quantitative brain MRI at 3.0 T is better than or at least comparable to the reproducibility at 1.5 T.

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