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Clinics in perinatology · Dec 2016
ReviewHigh-Frequency Ventilation as a Mode of Noninvasive Respiratory Support.
- Amit Mukerji and Michael Dunn.
- Division of Neonatology, Department of Pediatrics, McMaster Children's Hospital, McMaster University, 1280 Main Street West, HSC-4F1E, Hamilton, Ontario L8S 4K1, Canada. Electronic address: mukerji@mcmaster.ca.
- Clin Perinatol. 2016 Dec 1; 43 (4): 725-740.
AbstractHigh-frequency ventilation (HFV) as a mode of noninvasive respiratory support (NRS) in preterm neonates is gaining popularity. Benefits may accrue from combining the ventilatory efficiency of HFV delivered through a noninvasive interface, enhancing respiratory support while potentially limiting lung injury. Current evidence suggests that noninvasive HFV (NIHFV) may be superior to other NRS modes in eliminating carbon dioxide and preventing endotracheal ventilation after failure of other NRS modes. Animal data suggest NIHFV may promote improved alveolar development compared to endotracheal ventilation. However, adequately powered large-scale controlled trials are required to evaluate efficacy and safety prior to widespread use of NIHFV.Copyright © 2016 Elsevier Inc. All rights reserved.
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