• Angela Kribs.
• Department of Neonatology and Pediatric Intensive Care, Children's Hospital, University of Cologne, Kerpener Str 62, Cologne 50937, Germany. Electronic address: angela.kribs@uk-koeln.de.
• Clin Perinatol. 2016 Dec 1; 43 (4): 755-771.

AbstractRespiratory distress syndrome (RDS) caused by surfactant deficiency is major cause for neonatal mortality and short- and long-term morbidity of preterm infants. Continuous positive airway pressure and other modes of noninvasive respiratory support and intubation and positive pressure ventilation with surfactant therapy are efficient therapies for RDS. Because continuous positive airway pressure can fail in severe surfactant deficiency, and because traditional surfactant therapy requires intubation and positive pressure ventilation, this entails a risk of lung injury. Several strategies to combine noninvasive respiratory therapy with minimally invasive surfactant therapy have been described. Available data suggest that those strategies may improve outcome of premature infants with RDS.Copyright © 2016 Elsevier Inc. All rights reserved.

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