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Cancer investigation · Sep 2007
Case ReportsTemozolomide treatment of an adult with a relapsing medulloblastoma.
- X Durando, Emilie Thivat, Olivier Gilliot, Bernard Irthum, Pierre Verrelle, Catherine Vincent, and Jacques-Olivier Bay.
- Département D'Oncologie Médicale, Centre Jean Perrin, Clermont-Ferrand, France. Xavier.DURANDO@cjp.fr
- Cancer Invest. 2007 Sep 1; 25 (6): 470-5.
AbstractTemozolomide is an oral cytotoxic agent that has demonstrated its interest in high grade glioma tumors. This drug can be used either concomitantly with radiotherapy or as chemotherapy. The prognosis of relapsing medulloblastoma is poor and treatment is often difficult, especially after radiotherapy. Here, we report the use of temozolomide in an adult presenting relapsing medulloblastoma. An initial partial response was observed for this previously heavily treated patient. This observation suggests this drug may be useful in medulloblastoma, either as conventional chemotherapy or for use together with radiotherapy.
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