• Arch Pharm Res · Jul 2018

    Lifespan-extending property of 6-shogaol from Zingiber officinale Roscoe in Caenorhabditis elegans.

    • Eun Byeol Lee, Jun Hyeong Kim, Yeong Jee Kim, Yun Jeong Noh, Su Jin Kim, In Hyun Hwang, and Dae Keun Kim.
    • College of Pharmacy, Woosuk University, Jeonju, 55338, Republic of Korea.
    • Arch Pharm Res. 2018 Jul 1; 41 (7): 743-752.

    AbstractAging is a key risk factor for many diseases, understanding the mechanism of which is becoming more important for drug development given the fast-growing aging population. In the course of our continued efforts to discover anti-aging natural products, the active constituent 6-shogaol was isolated from Zingiber officinale Roscoe. The chemical structure of 6-shogaol was identified by comparison of its NMR data with literature values. The lifespan-extending effect of 6-shogaol was observed in a dose-dependent manner in Caenorhabditis elegans that has been widely used as a model organism for human aging studies. Mechanism of such action was investigated using C. elegans models, suggesting that 6-shogaol is capable of increasing stress tolerances via enzyme induction. The proposed mechanism was further supported by observation of the increase in SOD and HSP expressions upon treatment with 6-shogaol in transgenic strains of C. elegans which contain GFP-based reporters. In addition, the mechanism was elaborated by confirming that the effect observed for 6-shogaol is independent from other aging-related factors that are known to affect the aging process of C. elegans.

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