• J. Gastroenterol. · Jan 2003

    Case Reports

    Treatment with STI571, a tyrosine kinase inhibitor, for gastrointestinal stromal tumor with peritoneal dissemination and multiple liver metastases.

    • Satoshi Yamamoto, Shoji Kubo, Taichi Shuto, Takatsugu Yamamoto, Kazuhiro Hirohashi, Hiromu Tanaka, Shigekazu Takemura, Akishige Kanazawa, and Hiroaki Kinoshita.
    • Department of Gastroenterological and Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.
    • J. Gastroenterol. 2003 Jan 1; 38 (9): 896-9.

    BackgroundGastrointestinal stromal tumors (GISTs) are usually refractory to standard chemotherapeutic agents. We successfully treated a patient with a tyrosine kinase inhibitor (STI571) for GIST with peritoneal dissemination and liver metastases.MethodsIn a 32-year-old man presenting with abdominal pain from diffuse peritonitis, a GIST and associated perforated small intestine were resected. Multiple liver metastases were present. After therapies with microwave coagulation, ethanol injection, and local and systemic antineoplastic drugs (fluorouracil, cisplatin, tegafur-uracil, and tegafur) failed, investigational treatment with a tyrosine kinase inhibitor was initiated (STI571, 300 mg, p.o. daily).ResultsAnorexia and abdominal fullness resolved within a few days. At 24 days after initiation, positron emission tomography showed a remarkable decrease in the abdominal uptake of [18F] fluorodeoxyglucose. Adverse effects of STI571, including mild alopecia and anemia, were minimal.ConclusionsThe tyrosine kinase inhibitor STI571 may be effective against GISTs.

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