• Am. Rev. Respir. Dis. · May 1980

    Pulmonary alveolar proteinosis: the diagnosis by segmental lavage.

    • R J Martin, J J Coalson, R M Rogers, F O Horton, and L E Manous.
    • Am. Rev. Respir. Dis. 1980 May 1; 121 (5): 819-25.

    AbstractHistologic findings from segmental lavage material via the fiberoptic bronchoscope were evaluated as a means of diagnosing pulmonary alveolar proteinosis. Active cases of alveolar proteinosis yielded grossly opaque and/or milky effluents. The unique histologic findings in alveolar proteinosis included: (1) very few alveolar macrophages (2) large acellular eosinophilic bodies in a diffuse background of eosinophilic granules, and (3) periodic acid-Schiff staining of the proteinaceous material with a lack of significant alcian blue staining. Thus, the diagnosis of pulmonary alveolar proteinosis can be made by evaluation of the clinical setting and histologic findings of the effluent material from a segmental lavage.

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