• Adam Nović, Kairi Kõlves, Siobhan O'Dwyer, and Diego De Leo.
• *Australian Institute for Suicide Research and Prevention, National Centre of Excellence in Suicide Prevention, World Health Organization Collaborating Centre for Research and Training in Suicide Prevention†Centre for Health Practice Innovation, Griffith University, Brisbane, Qld, Australia.
• Clin J Pain. 2016 Apr 1; 32 (4): 351-64.

ObjectiveThe aim of this systematic review was to provide a picture of suicidality (suicide ideation and behavior, both fatal and nonfatal) among indviduals with migraine.BackgroundMigraine is a leading cause of disability around the world. Migraine may manifest with a number of symptoms, ranging from severe headaches to neurological sensory disturbances. Comorbid psychological conditions, such as depression, have also been linked to chronic migraine.Data SourcesArticles were retrieved from SCOPUS, PubMed, Proquest, and Web of Science.Search TermsSuicid* AND migrain* in English-language peer-reviewed journals between January 1, 1966 and December 31, 2014.Eligibility CriteriaOriginal research papers providing empirical evidence about the potential link between migraine and suicidal behaviors.ResultsInitial search identified 510 papers; the titles and abstracts of 360 unique results were examined for their relevance to the combination of migraine and suicidality. In total, 17 papers reporting original empirical analyses were included in this review.ConclusionsResearch has empirically documented a link between migraine and suicide ideation and behavior, particularly concerning the subtype of migraine with aura. Overall, nonfatal suicidal behavior among people with migraine has primarily been investigated, with only 2 studies analyzing suicide mortality. In addition, majority of studies originated from the United States or Canada (n=10). Future research should thoroughly define migraine and investigate link between migraine and suicide mortality.

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