• J Clin Neurosci · Apr 2020

    Case Reports

    Autoimmune polyradiculitis due to combination immunotherapy with ipilimumab and nivolumab for the treatment of metastatic melanoma.

    • Arian Lasocki and Kortnye Smith.
    • Department of Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; The Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia. Electronic address: arian.lasocki@petermac.org.
    • J Clin Neurosci. 2020 Apr 1; 74: 240-241.

    AbstractImmune checkpoint inhibitors, also known as immunotherapy, have revolutionised the treatment of metastatic melanoma, but are frequently associated with immune-related adverse events (irAEs) affecting a variety of organ systems. Here, we present a case of a patient with metastatic melanoma, being treated with combination ipilimumab-nivolumab, who developed a foot drop. MRI demonstrated enhancement of the nerve roots of the cauda equina. The patient had other irAEs, which warranted cessation of immunotherapy and the introduction of corticosteroids, and this also resulted in improvement in the patient's lower limb symptoms and MRI appearances. This confirmed an autoimmune polyradiculitis - a rare irAE.Copyright © 2020 Elsevier Ltd. All rights reserved.

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