• Int J Surg · Oct 2020

    Neck transection level and postoperative pancreatic fistula after pancreaticoduodenectomy: A retrospective cohort study of 195 patients.

    • Thomas Bardol, Julien Delicque, Margaux Hermida, Astrid Herrero, Boris Guiu, Jean-Michel Fabre, and Regis Souche.
    • Department of Digestive Surgery and Transplantation, University Hospital Center, Montpellier-Nimes University, 641 Avenue Du Doyen Gaston Giraud, 34090, Montpellier, France. Electronic address: t-bardol@chu-montpellier.fr.
    • Int J Surg. 2020 Oct 1; 82: 43-50.

    BackgroundThe aim of this study was to evaluate the impact of the level of neck transection on clinically relevant postoperative pancreatic fistula (CR-POPF) after standard pancreaticoduodenectomy (PD) with pancreaticojejunostomy.MethodA total of 195 patients with an early postoperative CT scan were retrospectively analyzed and divided into 2 groups (CR-POPF and No CR-POPF) in order to seek potential risk factors for CR-POPF. We focused our analysis on the relationship between CR-POPF and the level of neck transection, defined by measuring the distance between the left side of the portal vein and the remnant pancreatic stump on the postoperative CT scan.ResultCR-POPF occurred in 58 out of 195 PD (29.7%); grade B (17%) and grade C (12.7%). The Clavien-Dindo ≥ 3 morbidity rate was 33% (65/195) and the mortality rate was 2.5% (5/195). Multivariate analysis indicated that a 'right-sided' level of neck transection (P = 0.007), a firm pancreatic texture (P = 0.001), and a PD for non-pancreatic ductal adenocarcinoma histology (P = 0.032) were independent risk factors for CR-POPF. A full neck resection with systematic transection ≥7 mm at the left side of the portal vein seems to prevent CR-POPF harboring a protective effect (OR 0.056; 95% CI 0.003 to 0.978; P = 0.039).ConclusionHere we further consolidate the concept describing the pancreatic neck as a vascular watershed, showing that a long remnant pancreatic neck could be an independent risk factor for CR-POPF after PD (NCT03850236).Trial Registration Number And AgencyThe present study was approved by our local ethics committee and was declared on ClinicalTrials.gov (ID: NCT03850236).Copyright © 2020 IJS Publishing Group Ltd. Published by Elsevier Ltd. All rights reserved.

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