• Hiromichi Kawaida, Hiroshi Kono, Naohiro Hosomura, Hidetake Amemiya, Jun Itakura, Hideki Fujii, and Daisuke Ichikawa.
• First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan. kawaidah@yamanashi.ac.jp.
• World J. Gastroenterol. 2019 Jul 28; 25 (28): 3722-3737.

AbstractPostoperative pancreatic fistula (POPF) is one of the most severe complications after pancreatic surgeries. POPF develops as a consequence of pancreatic juice leakage from a surgically exfoliated surface and/or anastomotic stump, which sometimes cause intraperitoneal abscesses and subsequent lethal hemorrhage. In recent years, various surgical and perioperative attempts have been examined to reduce the incidence of POPF. We reviewed several well-designed studies addressing POPF-related factors, such as reconstruction methods, anastomotic techniques, stent usage, prophylactic intra-abdominal drainage, and somatostatin analogs, after pancreaticoduodenectomy and distal pancreatectomy, and we assessed the current status of POPF. In addition, we also discussed the current status of POPF in minimally invasive surgeries, laparoscopic surgeries, and robotic surgeries.

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