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- Fahad Edrees, Tingting Li, and Anitha Vijayan.
- Department of Medicine, Division of Nephrology, Washington University in St. Louis, St. Louis, MO.
- Adv Chronic Kidney Dis. 2016 May 1; 23 (3): 195-202.
AbstractProlonged intermittent renal replacement therapy (PIRRT) is becoming an increasingly popular alternative to continuous renal replacement therapy in critically ill patients with acute kidney injury. There are significant practice variations in the provision of PIRRT across institutions, with respect to prescription, technology, and delivery of therapy. Clinical trials have generally demonstrated that PIRRT is non-inferior to continuous renal replacement therapy regarding patient outcomes. PIRRT offers cost-effective renal replacement therapy along with other advantages such as early patient mobilization and decreased nursing time. However, due to lack of standardization of the procedure, PIRRT still poses significant challenges, especially pertaining to appropriate drug dosing. Future guidelines and clinical trials should work toward developing consensus definitions for PIRRT and ensure optimal delivery of therapy.Copyright © 2016 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.
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