• Christina Jerosch-Herold, Lee Shepstone, Julie Houghton, WilsonEdward C FECFCambridge Centre for Health Services Research, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom., and Julian Blake.
• School of Health Sciences, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, NR4 7TJ, United Kingdom.
• Muscle Nerve. 2019 Jul 1; 60 (1): 32-40.

IntroductionStudies of prognosis for surgery and corticosteroid injection for carpal tunnel syndrome (CTS) have considered only a limited range of explanatory variables for outcome.MethodsData were prospectively collected on patient-reported symptoms, physical and psychological functioning, comorbidity, and quality of life at baseline and every 6 months for up to 2 years. Outcomes were patient-rated change over a 6-month period and symptom-severity score at 18 months.ResultsIn total, 754 patients with CTS completed baseline questionnaires, and 626 (83%) completed follow-up to 18 months. Multivariable modeling identified, independent of symptom severity at outset, higher health utility, fewer comorbidities, and lower anxiety as significant predictors of better outcome from surgery. In patients treated by steroid injection, independent of symptom severity at outset, shorter duration of symptoms and having no prior injection were significant predictors of better outcome.DiscussionThese multivariable models of outcome may inform shared decision making about treatment for CTS. Muscle Nerve, 2019.© 2019 Wiley Periodicals, Inc.

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