• Tatsuya Hirose, Yasutaka Shinoda, Aya Yoshida, Machiko Kurimoto, Kouki Mori, Yuki Kawachi, Kouji Tanaka, Atsuko Takeda, Tomoaki Yoshimura, and Tadashi Sugiyama.
• Department of Pharmacy, Ogaki Municipal Hospital, Ogaki-shi, Gifu 503-8502, Japan; Laboratory of Pharmacy Practice and Social Science, Gifu Pharmaceutical University, Gifu-shi, Gifu 501-1196, Japan.
• Biomed Rep. 2016 Oct 1; 5 (4): 497-500.

AbstractThere are only a few treatment options for constipation and limited evidence of suitable treatments. Daiokanzoto (DKT) is a Kampo medicine often used clincally to treat constipation. DKT is a laxative used predominantly in Japan; however, clinical data on its efficacy and safety is lacking. Patients who used DKT, but were intolerant to either magnesium oxide (MgO; MgO group; n=16) or senna extract (Senna group; n=26) were included in the present study. The frequencies of their bowel movements were compared during the 1 week prior to and following DKT administration. Within 24 hours after DKT administration, 93.8% of the patients in the MgO group evacuated their bowels. The median bowel movement frequency 1 week prior to DKT administration was 2.5 and 1 week after DKT administration was significantly increased to 7.5. In the Senna group, within 24 h of DKT administration, 80.8% of the patients evacuated their bowels. The median bowel movement frequency 1 week prior to the DKT treatment was 2.0, which significantly increased to 8.5 1 week after the administration of DKT. The adverse events from DKT treatment were mild and controllable.

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