• Adv Exp Med Biol · Jan 2013

    Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: simulating pH changes.

    • Tharindi Hapuarachchi, Tracy Moroz, Alan Bainbridge, David Price, Ernest Cady, Esther Baer, Kevin Broad, Mojgan Ezzati, David Thomas, Xavier Golay, Nicola J Robertson, and Ilias Tachtsidis.
    • CoMPLEX, University College London, London, UK. t.hapuarachchi@ucl.ac.uk.
    • Adv Exp Med Biol. 2013 Jan 1; 789: 331-337.

    AbstractWe describe the extension of a computational model of blood flow and metabolism in the piglet brain to investigate changes in neonatal intracellular brain pH during hypoxia-ischemia (HI). The model is able to simulate near-infrared spectroscopy (NIRS) and magnetic resonance spectroscopy (MRS) measurements obtained from HI experiments conducted in piglets. We adopt a method of using (31)P-MRS data to estimate of intracellular pH and compare measured pH and oxygenation with their modelled counterparts. We show that both NIRS and MRS measurements are predicted well in the new version of the model.

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