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- S Kinuya, K Yokoyama, S Konishi, X F Li, N Watanabe, N Shuke, T Aburano, T Takayama, T Michigishi, and N Tonami.
- Department of Nuclear Medicine, Kanazawa University School of Medicine, Ishikawa, Japan. kinuya@med.kanazawa-u.ac.jp
- Ann Nucl Med. 2000 Apr 1; 14 (2): 139-41.
Abstract99mTc-HL91, a hypoxic marker, may be a predictor of tumor response to radiotherapy and an indicator of tumor oxygenation in the course of treatment. In this study, serial changes in 99mTc-HL91 uptake were observed in the normoxic condition in a human bladder cancer cell line exposed to a single dose or a fractionated dose of 10 Gy with an x-ray beam. The uptake per cell increased during cell growth retardation induced by the irradiation. This finding indicates that 99mTc-HL91 uptake is affected by injury to cells due to radiation; it may therefore be difficult to correctly assess the tissue oxygenation status during radiotherapy with 99mTc-HL91.
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