• Hongying Dai, Delwyn Catley, Kimber P Richter, Kathy Goggin, and Edward F Ellerbeck.
• The Center for Children's Healthy Lifestyles and Nutrition, Children's Mercy Kansas City, Kansas City, Missouri; hdai@cmh.edu.
• Pediatrics. 2018 May 1; 141 (5).

BackgroundCigarettes have been strongly associated with subsequent marijuana use among adolescents, but electronic cigarettes (e-cigarettes) are now rapidly replacing traditional cigarettes among youth. This study examines associations between youth e-cigarette use and subsequent marijuana use in a national sample.MethodsYouth (aged 12-17 years) never marijuana users at wave 1 (n = 10 364; 2013-2014) from the Population Assessment of Tobacco and Health study were followed-up in 1 year (wave 2, 2014-2015). Multivariable logistic regressions were performed to evaluate associations between e-cigarette use at wave 1 and ever/heavy marijuana use in the past 12 months (P12M) and at wave 2.ResultsAmong never marijuana users, e-cigarette ever use (versus never use) at wave 1 was associated with increased likelihood of marijuana P12M use (adjusted odds ratio [aOR] = 1.9; 95% confidence interval [CI]: 1.4-2.5) at wave 2. There was a significant interaction between e-cigarette use and age (P < .05) with aOR = 2.7 (95% CI: 1.7-4.3) for adolescents aged 12 to 14 and aOR = 1.6 (95% CI: 1.2-2.3) for adolescents aged 15 to 17. The association with heavy marijuana use was significant among younger adolescents (aOR = 2.5; 95% CI: 1.2-5.3) but was not among older adolescents. Heavier e-cigarette use at wave 1 yielded higher odds of P12M and heavy marijuana use at wave 2 for younger adolescents.ConclusionsE-cigarette use predicts subsequent marijuana use among youth, with a stronger associations among young adolescents. Reducing youth access to e-cigarettes may decrease downstream marijuana use.Copyright © 2018 by the American Academy of Pediatrics.

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