• Jing Hao and Pengfei Zhao.
• Department of Breast Surgery, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, Lishui, Zhejiang 323000, China.
• J Cancer Res Ther. 2015 Aug 1; 11 Suppl 1: C59-62.

ObjectiveThe relationship between methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphisms and lung cancer susceptibility is controversial according to the case-control or cohort study. We perform this meta-analysis to evaluate the association between MTHFR 677C>T polymorphisms and lung cancer risk based on Chinese Han population.Materials And MethodsWe searched the databases of Medline, PubMed, EMBASE, Wanfang, and CNIK to find the case-control or cohort study about the relationship between MTHFR 677C>T polymorphisms and lung cancer susceptibility. The genotype of CC, CT, and TT for the lung cancer patients and healthy controls were extracted and aggregated by meta-analysis method. The relationship between MTHFR 677C>T polymorphisms and lung cancer susceptibility was assessed by odds ratio (OR) and its 95% confidence interval (CI).ResultsAccording to the inclusion and exclusion criteria, we finally included 14 case-control studies, with 2845 lung cancer patients and 3691 healthy controls in this meta-analysis. The pooled results showed the OR were 1.02 (95% CI: 0.93-1.13), 0.66 (95% CI: 0.60-0.73), and 1.25 (95% CI: 1.07-1.47) in recessive genetic model, dominant genetic model, and homozygous model, respectively.ConclusionChinese Han people with TT/CT genotype of MTHFR gene may have increased the risk of developing breast cancer.

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