• Yusuke Tajima, Hideyuki Ishida, Azusa Yamamoto, Noriyasu Chika, Hisashi Onozawa, Takeaki Matsuzawa, Kensuke Kumamoto, Keiichiro Ishibashi, and Erito Mochiki.
• Department of General and Digestive Tract Surgery, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, 350-8550, Japan. tajifeyfey@yahoo.co.jp.
• Surg. Today. 2016 Jun 1; 46 (6): 735-40.

PurposeTo validate the usefulness of sennoside as a substitute for polyethylene glycol (PEG) as a mechanical bowel preparation (MBP) for elective colon cancer surgery.MethodsWe performed a prospective randomized non-inferiority trial comparing the use of sennoside and PEG in MBP for elective colon cancer surgery, in terms of the risk of surgical site infection (SSI) and the feasibility of surgery.ResultsThe overall incidence of SSIs was 2.9 % in the sennoside group (n = 68) and 6.3 % in the PEG group (n = 63) with a difference of 3.4 % (95 % confidence interval 6.9-10.6 %). The intraoperative spillage of the stool materials in the sennoside and PEG groups was 4.4 and 3.1 %, respectively, and was not significantly different (p = 0.71), even the upstream stool consistency, was more frequently observed to be non-stool in the PEG group (65.1 vs. 30.9 %, p < 0.01).ConclusionMBP with sennoside could be a substitution for PEG in elective colon cancer surgery.

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