• Niloufar Sadeghi, Isabelle Salmon, Bich Ngoc Thanh Tang, Vincent Denolin, Marc Levivier, David Wikler, Sandrine Rorive, Danielle Balériaux, Thierry Metens, and Serge Goldman.
• Department of Radiology, Hôpital Erasme, Brussels, Belgium. nsadeghi@ulb.ac.be
• J Magn Reson Imaging. 2006 Nov 1; 24 (5): 989-94.

PurposeTo evaluate in brain gliomas the relationship between tumor vascularity measured by MR-based maximum regional cerebral blood volume (rCBV) and tumor amino-acid metabolism based on maximum carbon-11 methionine (MET) uptake on positron emission tomography (PET).Materials And MethodsEighteen patients with histologically proven primary brain gliomas were included in the study. In addition to conventional MR sequences, dynamic MR images, including a first-pass gadopentetate dimeglumine T2*-weighted echo-planar perfusion sequence and a PET study using MET, were acquired. Eleven patients had low-grade gliomas, and seven had high-grade gliomas. rCBV ratios and MET uptake ratios normalized to the contralateral white matter (WM) corresponding values were measured in each tumor. Both maximum rCBV ratios and maximum MET uptake ratios were correlated to histopathology. The maximum rCBV ratios were correlated to the maximum MET uptake ratios.ResultsBoth the maximum rCBV ratios and maximum MET uptake ratios of high-grade gliomas were significantly higher than those of low-grade gliomas (P<0.05). There was a significant positive correlation between maximum rCBV ratios and maximum MET uptake ratios (Spearman: r=0.89, P<0.00001).ConclusionThe maximum rCBV ratio and maximum MET uptake ratio are significantly correlated in gliomas, reflecting a close link between amino acid uptake and vascularity in these tumors.Copyright (c) 2006 Wiley-Liss, Inc.

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