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J Natl Compr Canc Netw · Jan 2003
ReviewEpidermal growth factor receptor as a target in cancer therapy.
- Edward S Kim.
- Department of Thoracic/Head and Neck Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA. edkim@mdanderson.org
- J Natl Compr Canc Netw. 2003 Jan 1; 1 Suppl 1: S87-95.
AbstractEpithelial cancers have been found to overexpress the receptor to epidermal growth factor (EGFR). These include head and neck, breast, colon, lung, prostate, kidney, ovary, brain, pancreas, and bladder. A number of strategies to block EGFR have been developed to inhibit tumor proliferation and to improve overall clinical outcome because overexpression of the receptor has been associated with a poorer prognosis in cancer patients. Strategies include using monoclonal antibodies to EGFR, tyrosine kinase inhibitors, ligand-linked toxins, and antisense approaches. Antibodies such as IMC-C225 specifically target EGFRs, whereas tyrosine kinase inhibition by many small molecules is less specific but is also effective. This report focuses on EGFR and novel compounds that target it.
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