• H Hamada, T Nishii, S Tamura, H Tanaka, T Wakayama, and N Sugano.
• Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
• Osteoarthr. Cartil. 2015 Oct 1; 23 (10): 1776-9.

ObjectiveTo compare changes in T1rho and T2 values of the femoral cartilage in porcine knee joints under staged loading and unloading conditions.DesignSixteen porcine knee joints with intact capsules and surrounding muscle were imaged using a custom-made pressure device and 3.0 T magnetic resonance imaging. Sagittal T1rho and T2 images were obtained for the lateral and medial condyles under the following compression loads: none (Load 0), 140 N (Load 140), 300 N (Load 300), and no compression after decompression (Post-load). The percentage changes of cartilage T1rho and T2 values under each loading condition from those at Load 0 were calculated for weight-bearing overall and eight subdivided regions of interest (ROIs) in both femoral condyles. The actual contact pressure under Load 140 and Load 300 was measured using pressure-sensitive film.ResultsFor the overall ROI, the mean decreases of T1rho and T2 values were 4.4% and 5.1% under Load 140% and 10.9% and 10.6% under Load 300 in the medial condyle and were 5.2% and 4.0% under Load 140% and 10.6% and 6.0% under Load 300 in the lateral condyle. In the medial condyle, the actual contact pressure correlated highly with percentage changes in T1rho (r = -0.84, P < 0.01) and T2 (r = -0.79, P < 0.01), but those correlations were relatively low in the lateral condyle.ConclusionAlthough there were side-dependent variations in the correlations with actual pressure, cartilage T1rho and T2 showed similarly sensitive responses to applied load.Copyright © 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

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