• Am. J. Hematol. · Mar 2007

    Case Reports

    Megakaryocytic blast crisis as first presentation of chronic myeloid leukemia.

    • L Campiotti, A M Grandi, M G Biotti, C Ultori, F Solbiati, R Codari, and A Venco.
    • Dipartimento di Medicina Clinica Università dell'Insubria, Varese, Italy. leonardo.campiotti@uninsubria.it
    • Am. J. Hematol. 2007 Mar 1; 82 (3): 231-3.

    AbstractWe describe an extremely rare case of megakaryocytic blast crisis as first presentation of chronic myeloid leukemia. The patient had a very high platelet count and developed an ischemic stroke with seizures. She was treated with hydroxyurea, platelet apheresis, ARA-C, and idarubicin in order to obtain a prompt reduction of thrombocytosis and then with imatinib 600 mg/die PO. The therapy induced a complete hematological remission with a resolution of neurological signs within 4 weeks.Copyright (c) 2006 Wiley-Liss, Inc.

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