• J. Clin. Microbiol. · Nov 2014

    Comparative Study

    Reassessment of genotype 1 hepatitis C virus subtype misclassification by LiPA 2.0: implications for direct-acting antiviral treatment.

    • Javier R Guelfo, Juan Macias, Karin Neukam, Federico A Di Lello, Jose A Mira, Nicolas Merchante, María Mancebo, Rocío Nuñez-Torres, Juan A Pineda, and Luis M Real.
    • Unidad de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Seville, Spain Instituto de Biomedicina de Seville (IBIS), Seville, Spain.
    • J. Clin. Microbiol. 2014 Nov 1; 52 (11): 4027-9.

    AbstractThe accuracy of LiPA 2.0 for hepatitis C virus 1 (HCV-1) subtype classification was analyzed. LiPA 2.0 genotype results from 101 HCV-1-infected patients were compared to genotype findings determined by direct core sequencing. Eleven (11%) samples were misclassified. Given the influence of the HCV-1-subtype in the anti-HCV therapy response, an alternative classification method is warranted. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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