• Michael D Sawdey, Hannah R Day, Blair Coleman, Lisa D Gardner, Sarah E Johnson, Jean Limpert, Hoda T Hammad, Maciej L Goniewicz, David B Abrams, Cassandra A Stanton, Jennifer L Pearson, Annette R Kaufman, Heather L Kimmel, Cristine D Delnevo, Wilson M Compton, Maansi Bansal-Travers, Raymond S Niaura, Andrew Hyland, and Bridget K Ambrose.
• Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD, USA. Electronic address: Michael.Sawdey@fda.hhs.gov.
• Addict Behav. 2019 Apr 1; 91: 51-60.

IntroductionImproved understanding of the distribution of traditional risk factors of cigarette smoking among youth who have ever used or are susceptible to e-cigarettes and cigarettes will inform future longitudinal studies examining transitions in use.MethodsMultiple logistic regression analysis was conducted using data from youth (ages 12-17 years) who had ever heard of e-cigarettes at baseline of the PATH Study (n = 12,460) to compare the distribution of risk factors for cigarette smoking among seven mutually exclusive groups based on ever cigarette/e-cigarette use and susceptibility status.ResultsCompared to committed never users, youth susceptible to e-cigarettes, cigarettes, or both had increasing odds of risk factors for cigarette smoking, with those susceptible to both products at highest risk, followed by cigarettes and e-cigarettes. Compared to e-cigarette only users, dual users had higher odds of nearly all risk factors (aOR range = 1.6-6.8) and cigarette only smokers had higher odds of other (non-e-cigarette) tobacco use (aOR range = 1.5-2.3), marijuana use (aOR = 1.9, 95%CI = 1.4-2.5), a high GAIN substance use score (aOR = 1.9, 95%CI = 1.1-3.4), low academic achievement (aOR range = 1.6-3.4), and exposure to smoking (aOR range = 1.8-2.1). No differences were observed for externalizing factors (depression, anxiety, etc.), sensation seeking, or household use of non-cigarette tobacco.ConclusionsAmong ever cigarette and e-cigarette users, dual users had higher odds of reporting traditional risk factors for smoking, followed by single product cigarette smokers and e-cigarette users. Understanding how e-cigarette and cigarette users differ may inform youth tobacco use prevention efforts and advise future studies assessing probability of progression of cigarette and e-cigarette use.Published by Elsevier Ltd.

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