• Bulletin du cancer · Jan 2007

    Review

    [Angiogenesis targeting in gastro-intestinal cancers].

    • Jean-Baptiste Meric.
    • Service d'oncologie médicale, Groupe hospitalier Pitié-Salpêtrière, boulevard de l'Hôpital, 75013 Paris. jean-baptiste.meric@psl.aphp.fr
    • Bull Cancer. 2007 Jan 1; 94 (7 Suppl): F207-15.

    AbstractColorectal cancers have been the first cancers to benefit from an efficient anti-angiogenic treatment, represented by bevacizumab, which has been approved for first-line metastatic treatment in combination with reference chemotherapies and which is under study in the adjuvant setting. Other gastro-intestinal malignancies appear less responsive to anti-angiogenic therapy, but inhibitors of the VEGF receptors (sorafenib, sunitinib, axitinib) are in development with encouraging results. The safety profile of anti-angiogenic agents is quite different from that of classical chemotherapy and may require a modification of treatment strategies.

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