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- Christopher M Coleman, Thiagarajan Venkataraman, Ye V Liu, Gregory M Glenn, Gale E Smith, David C Flyer, and Matthew B Frieman.
- University of Maryland, School of Medicine, 685 West Baltimore St, Baltimore, MD 21201, United States.
- Vaccine. 2017 Mar 14; 35 (12): 1586-1589.
AbstractThe Middle East respiratory syndrome coronavirus (MERS-CoV) was first discovered in late 2012 and has gone on to cause over 1800 infections and 650 deaths. There are currently no approved therapeutics or vaccinations for MERS-CoV. The MERS-CoV spike (S) protein is responsible for receptor binding and virion entry to cells, is immunodominant and induces neutralizing antibodies in vivo, all of which, make the S protein an ideal target for anti-MERS-CoV vaccines. In this study, we demonstrate protection induced by vaccination with a recombinant MERS-CoV S nanoparticle vaccine and Matrix-M1 adjuvant combination in mice. The MERS-CoV S nanoparticle vaccine produced high titer anti-S neutralizing antibody and protected mice from MERS-CoV infection in vivo.Copyright © 2017 Elsevier Ltd. All rights reserved.
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