• J. Intern. Med. · Dec 2021

    Letter

    Immunogenicity of SARS-CoV-2 mRNA vaccine in solid organ transplant recipients.

    • Inge K Holden, Claus Bistrup, Anna Christine Nilsson, Janne Fuglsang Hansen, Rozeta Abazi, Jesper Rømhild Davidsen, Mikael Kjaer Poulsen, Susan Olaf Lindvig, Ulrik S Justesen, and Isik Somuncu Johansen.
    • Department of Infectious Diseases, Odense University Hospital, Odense, Denmark.
    • J. Intern. Med. 2021 Dec 1; 290 (6): 126412671264-1267.

    BackgroundIt is currently not well described if a two-dose regimen of a Covid-19 vaccine is sufficient to elicit an immune response in solid organ transplant (SOT) recipients.ResultsA total of 80 SOT recipients completed a two-dose regimen with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA vaccine. Only 35.0% (n = 28) were able to mount a positive IgG immune response 6 weeks after the second dose of vaccine.ConclusionThis emphasizes that SOT recipients need continued use of personal protective measures. Future studies need to closely examine the cellular immune response in patients with compromised antibody response to Covid-19 vaccination.© 2021 The Authors. Journal of Internal Medicine published by John Wiley & Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine.

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