• Hitoshi Ishikawa, Hiroshi Tsuji, Tadashi Kamada, Takeshi Yanagi, Jun-Etsu Mizoe, Tatsuaki Kanai, Shinroku Morita, Masaru Wakatsuki, Jun Shimazaki, Hirohiko Tsujii, and Working Group for Genitourinary Tumors.
• Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Inage-ku, Chiba-city, Japan.
• Radiother Oncol. 2006 Oct 1; 81 (1): 57-64.

Background And PurposeTo determine the efficacy and feasibility of carbon ion radiotherapy (C-ion RT) for prostate cancer.Patients And MethodsBetween April 2000 and November 2003, 175 patients received C-ion RT using a recommended dose fractionation (66.0 GyE/20 fractions) established from prior studies. C-ion RT alone was performed for 33 patients constituting a low-risk group (Stage < or =T2a and PSA <20 ng/ml and Gleason score < or =6); the remaining 142 high-risk patients received an additional androgen deprivation therapy (ADT).ResultsThe 4-year overall survival and bNED rates were 91% and 87%, respectively. Local control was achieved in all but one patient. The 4-year bNED rates were 87% in the low-risk group and 88% in the high-risk group. In very advanced diseases (Stage > or= T3a or PSA > or= 20 ng/ml or Gleason score > or =8), there was significant difference in the bNED rate according to period of ADT administration (ADT > or =24 months: 93%, ADT <24 months: 73%, p<0.01). Grade 2 late toxicities developed in 4 patients (2%) for the rectum and 9 patients (5%) for the genitourinary system but no Grade 3 or higher toxicity was observed.ConclusionsThe effectiveness of C-ion RT for prostate cancer has been well confirmed. Based on these results, new study of a C-ion RT modified for the administration strategy of ADT according to the patient risk has been started by dividing patients into 3 groups, high-risk, intermediate-risk, and low-risk.

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