-
Am. J. Obstet. Gynecol. · Mar 1999
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialDouble-blind comparison of carbetocin versus oxytocin in prevention of uterine atony after cesarean section.
- J Dansereau, A K Joshi, M E Helewa, T A Doran, I R Lange, E R Luther, D Farine, M L Schulz, G L Horbay, P Griffin, and W Wassenaar.
- British Columbia Women's Hospital, University of British Columbia, Vancouver, British Columbia.
- Am. J. Obstet. Gynecol. 1999 Mar 1;180(3 Pt 1):670-6.
ObjectiveThe goal of this study was to compare carbetocin, a long-acting oxytocin analog, with oxytocin in the prevention of uterine atony after cesarean section.Study DesignWe enrolled 694 patients undergoing elective cesarean section in a Canadian multicenter, double-blind, randomized clinical trial. We compared the effect of a single 100 microg dose of carbetocin with that of a standard 8-hour infusion of oxytocin. The primary outcome was the proportion of patients requiring additional oxytocic intervention for uterine atony. A variable sample size, sequential design was used.ResultsThe overall oxytocic intervention rate was 7.4%. The odds of treatment failure requiring oxytocic intervention was 2.03 (95% confidence interval 1.1 to 2.8) times higher in the oxytocin group compared with the carbetocin group, respectively, 32 of 318 (10.1%) versus 15 of 317 (4.7%), P <.05.ConclusionsCarbetocin, a new drug for the prevention of uterine atony, appears to be more effective than a continuous infusion of oxytocin and has a similar safety profile.
This article appears in the collection: Carbetocin at Cesarean Section.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*
,_underline_
or**bold**
. - Superscript can be denoted by
<sup>text</sup>
and subscript<sub>text</sub>
. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3.
, hyphens-
or asterisks*
. - Links can be included with:
[my link to pubmed](http://pubmed.com)
- Images can be included with:
![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
- For footnotes use
[^1](This is a footnote.)
inline. - Or use an inline reference
[^1]
to refer to a longer footnote elseweher in the document[^1]: This is a long footnote.
.