• Alexander Simonis, Sebastian J Theobald, Gerd Fätkenheuer, Jan Rybniker, and Jakob J Malin.
• Department I of Internal Medicine, Division of Infectious Diseases, University of Cologne, Cologne, Germany.
• EMBO Mol Med. 2021 Jan 11; 13 (1): e13105.

AbstractThe ongoing SARS-CoV-2 pandemic stresses the need for effective antiviral drugs that can quickly be applied in order to reduce morbidity, mortality, and ideally viral transmission. By repurposing of broadly active antiviral drugs and compounds that are known to inhibit viral replication of related viruses, several advances could be made in the development of treatment strategies against COVID-19. The nucleoside analog remdesivir, which is known for its potent in vitro activity against Ebolavirus and other RNA viruses, was recently shown to reduce the time to recovery in patients with severe COVID-19. It is to date the only approved antiviral for treating COVID-19. Here, we provide a mechanism and evidence-based comparative review of remdesivir and other repurposed drugs with proven in vitro activity against SARS-CoV-2.© 2020 The Authors. Published under the terms of the CC BY 4.0 license.

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