• Teresa Cobo, Montse Palacio, Aleix Navarro-Sastre, Antonia Ribes, Jordi Bosch, Xavier Filella, and Eduard Gratacós.
• Department of Maternal-Fetal Medicine, Institut de Investigacions Biomèdiques August Pi-Sunyer, Hospital Clínic, University of Barcelona, Barcelona, Spain.
• Am. J. Obstet. Gynecol. 2009 May 1; 200 (5): 499.e1-6.

ObjectiveTo assess proteomic biomarkers and interleukin-6 alone or in combination to predict intraamniotic infection, preterm birth, and neonatal morbidity in preterm labor with intact membranes.Study DesignAmniotic fluid interleukin-6 and selected proteomic biomarkers were assayed from 86 patients with preterm labor and intact membranes (22-36 weeks). The predictive value of each marker alone or in combination was evaluated for intraamniotic infection, preterm birth, and neonatal composite morbidity.ResultsBoth interleukin-6 (odds ratio, 19.5; P = .012) and proteomic biomarkers (odds ratio, 25.2; P = .001) were statistically independent predictors of intraamniotic infection with sensitivity, positive predictive value, and false-positive rates of 25%, 17.6%, and 20% when 1 marker was present and of 75%, 75%, and 4.3% when both were detected. Their combination did not improve prediction of preterm birth or neonatal morbidity.ConclusionThe combined use of proteomic biomarkers and interleukin-6 to predict intraamniotic infection shows better accuracy than when used alone.

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