• Ozsancak UgurluAylinADepartment of Pulmonary Disease, Baskent University, Istanbul, Turkey. aozsancak@hotmail.com., Samy S Sidhom, Ali Khodabandeh, Michael Ieong, Chester Mohr, Denis Y Lin, Irwin Buchwald, Imad Bahhady, John Wengryn, Vinay Maheshwari, and Nicholas S Hill.
• Department of Pulmonary Disease, Baskent University, Istanbul, Turkey. aozsancak@hotmail.com.
• Respir Care. 2016 Jan 1; 61 (1): 36-43.

BackgroundThe prevalence of chronic disease and do-not-intubate status increases with age. Thus, we aimed to determine characteristics and outcomes associated with noninvasive ventilation (NIV) use for acute respiratory failure (ARF) in different age groups.MethodsA database comprising prospective data collected on site on all adult patients with ARF requiring ventilatory support from 8 acute care hospitals in Massachusetts was used.ResultsFrom a total of 1,225 ventilator starts, overall NIV utilization, success, and in-hospital mortality rates were 22, 54, and 18% in younger (18-44 y); 34, 65, and 13% in middle-aged (45-64 y); 49, 68, and 17% in elderly (65-79 y); and 47, 76, and 24% in aged (≥ 80 y) groups, respectively (P < .001, P = .08, and P = .11, respectively). NIV use for cardiogenic pulmonary edema and subjects with a do-not-intubate order increased significantly with advancing age (25, 57, 57, and 74% and 7, 12, 18, and 31%, respectively, in the 4 age groups [P < .001 and P = .046, respectively]). For subjects receiving NIV with a do-not-intubate order, success and in-hospital mortality rates were similar in different age groups (P = .27 and P = .98, respectively).ConclusionsNIV use and a do-not-intubate status are more frequent in subjects with ARF ≥ 65 y than in those <65 y, especially for subjects with cardiogenic pulmonary edema. However, NIV success and mortality rates were similar between age groups. (ClinicalTrials.gov registration NCT00458926.).Copyright © 2016 by Daedalus Enterprises.

31 keywords...

hide…