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Comparative Study Clinical Trial Controlled Clinical Trial
Molindone hydrochloride treatment of hospitalized children with conduct disorder.
- L L Greenhill, M Solomon, R Pleak, and P Ambrosini.
- J Clin Psychiatry. 1985 Aug 1; 46 (8 Pt 2): 20-5.
AbstractTreatment-emergent symptoms and behavioral changes were assessed during an 8-week double-blind study comparing molindone and thioridazine in 31 aggressive hospitalized children (ages 6-11). Molindone was found to be as effective as thioridazine in this sample. Adverse effects differed (nonsignificantly) for the two groups, with more sedation in the thioridazine-treated children. Clinical records from 6 adolescent inpatients treated with molindone were reviewed as a comparison group. Molindone is a relatively safe neuroleptic for child and adolescent inpatients because of its short half-life and minimal prolonged tissue accumulation. Additional studies on different child populations are necessary before the proper indications for molindone usage in the pediatric group can be established.
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