• Eliahu Bekhor, Jacquelyn Carr, Margaret Hofstedt, Brianne Sullivan, Daniel Solomon, Natasha Leigh, Nathan Bolton, Benjamin Golas, Umut Sarpel, Daniel Labow, and Deepa Magge.
• Division of Surgical Oncology, Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, USA. elibekhor@gmail.com.
• Ann. Surg. Oncol. 2020 May 1; 27 (5): 1448-1455.

IntroductionOffering iterative cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) for recurrence of peritoneal carcinomatosis (PC) poses a surgical dilemma. Safety of this repeated operation in the short and long term has not been largely investigated.MethodsPatients with PC who underwent 377 CRS/HIPEC procedures between 2007 and 2018 at our institution were included from a prospectively maintained database. Outcomes for patients who had singular CRS/HIPEC were compared with those for patients who had repeated CRS/HIPEC.ResultsOverall, there were 325 singular and 52 iterative CRS/HIPEC procedures performed during this time period. Age, sex, and ASA class were comparable between cohorts (p = NS). Optimal cytoreduction, mean operative time, mean length of hospital stay, 90-day major morbidity, and 90-day mortality were also similar. At a median follow-up of 24 months, there was no significant difference in recurrence rate (%, 60 vs 63, p = 0.76), disease-free survival (mean months, 19 vs 15, p = 0.30), and overall survival (mean months, 32 vs 27, p = 0.69). The iterative CRS/HIPEC group had significantly higher rates of major late complications than the singular CRS/HIPEC group (%, 18 vs 40, p < 0.01).ConclusionRepeated CRS/HIPEC for PC has similar perioperative morbidity and mortality, as well as long-term oncological benefits, when compared with singular CRS/HIPEC. However, more than twice as many patients undergoing iterative CRS/HIPEC suffered from major late complications.

40 keywords...

hide…