• J Cutan Med Surg · Jan 2016

    Review

    Evaluation of Evidence for Acne Remission With Oral Isotretinoin Cumulative Dosing of 120-150 mg/kg.

    • Jerry Tan, Sanja Knezevic, Sanwarjit Boyal, Brad Waterman, and Toni Janik.
    • Department of Medicine, University of Western Ontario, London, ON, Canada Windsor Clinical Research Inc, Windsor, ON, Canada jerrytan@bellnet.ca.
    • J Cutan Med Surg. 2016 Jan 1; 20 (1): 13-20.

    BackgroundOral isotretinoin (ISO) is the standard of care for severe inflammatory acne and a threshold dose of 120-150 mg/kg is widely regarded as increasing remission potential.ObjectiveOur objective was to evaluate the evidence underlying ISO dosing of 120-150 mg/kg in acne remission.MethodsA systematic literature search was performed using keywords "acne," "isotretinoin," "efficacy," "dosing," "relapse," and "remission."ResultsDefinitions for acne clearance, relapse/remission, and treatment endpoint vary widely across studies. Only 2 studies explicitly evaluated the cumulative dose of 120-150 mg/kg for induction of acne remission-both low grade.ConclusionThe threshold dose of 120-150 mg/kg for oral ISO is based on past parameters of treatment duration and prior studies used vague or inconsistent definitions of clearance and remission. Optimal cumulative doses of ISO required to induce remission appears to vary with severity.© The Author(s) 2015.

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