• J. Gerontol. A Biol. Sci. Med. Sci. · Apr 2009

    White blood cell counts, insulin-like growth factor-1 levels, and frailty in community-dwelling older women.

    • Sean X Leng, Will Hung, Anne R Cappola, Qilu Yu, Qian-Li Xue, and Linda P Fried.
    • Division of Geriatric Medicine and Gerontology, 5505 Hopkins Bayview Circle, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA. sleng1@jhmi.edu
    • J. Gerontol. A Biol. Sci. Med. Sci. 2009 Apr 1; 64 (4): 499-502.

    BackgroundElevated white blood cell (WBC) counts and decreased insulin-like growth factor-1 (IGF-1) levels are individually associated with frailty in older adults. WBC subpopulations are known to produce IGF-1 and express IGF-1 receptors in vitro. However, in vivo relationships between WBC and IGF-1 and their joint contribution to frailty have not been investigated.MethodsBaseline data from 696 community-dwelling older women in the Women's Health and Aging Study I were included in this cross-sectional analysis. Multivariate linear regression analysis was performed to assess the relationship between WBC counts and IGF-1 levels. Odds ratios (ORs) for frailty were evaluated across tertiles of WBC counts and IGF-1 levels, adjusting for age, race, education, body mass index, and smoking.ResultsWBC counts correlated with IGF-1 levels (Spearman coefficient: .10, p < .01). Compared with participants in the low WBC and high IGF-1 tertiles (reference group), those in the low WBC and low IGF-1 tertiles had OR of 2.33 for frailty (95% confidence interval [CI]: 1.04-3.65, p < .05), those in the high WBC and high IGF-1 tertiles had OR of 3.86 (95% CI: 1.13-4.07, p < .01), and those in the high WBC and low IGF-1 tertiles had OR of 3.61 (95% CI: 1.64-4.97, p < .01), adjusting for covariates.ConclusionsThese findings demonstrate in vivo correlation between WBC and IGF-1. They suggest U-shaped joint associations of WBC and IGF-1 with frailty, with the strongest association at adverse levels of both. They also provide a basis for further investigation into the complex immune-endocrine dysregulations in frailty.

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