• John M Murkin, Moshe Kamar, Zmira Silman, Michal Balberg, and Sandra J Adams.
• Department of Anesthesiology and Perioperative Medicine, Schulich School of Medicine, University of Western Ontario, London, Canada. Electronic address: john.murkin@lhsc.on.ca.
• J. Cardiothorac. Vasc. Anesth. 2015 Oct 1; 29 (5): 1187-93.

ObjectiveThis was a pilot study comparing the ability of a new ultrasound-tagged near-infrared (UT-NIR) device to detect cerebral autoregulation (CA) in comparison to transcranial Doppler (TCD).DesignAn unblinded, prospective, clinical feasibility study.SettingTertiary-care university hospital cardiac surgical operating rooms.ParticipantsTwenty adult patients undergoing cardiac surgery with cardiopulmonary bypass (CPB).InterventionsThere were no clinical interventions based on study monitoring devices, but a continuous correlation analysis of digital data from transcranial Doppler (TCD) velocity was compared with a novel UT-NIR device and correlation analysis of change signals versus mean arterial pressure was performed in order to detect presence or absence of intact CA and for determination of the lower limit of cerebral autoregulation during CPB.Measurements And Main ResultsSimilar and highly significant concordance (κ = 1.00; p<0.001) was demonstrated between the 2 methodologies for determination of CA, indicating good correlation between the 2 methodologies. Intact CA was absent in 2 patients during CPB, and both devices were able to detect this.ConclusionsTo the authors' knowledge this is the first clinical report of a UT-NIR device that shows promise as a clinically useful modality for detection of CA and the lower limit of cerebral autoregulation. The utility of UT-NIR was demonstrated further during times at which extensive usage of electrocautery or functional absence of the transcranial window rendered TCD uninterpretable.Copyright © 2015 Elsevier Inc. All rights reserved.

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