• Byung-moon Choi, Soo-kyung Park, Sung Shin, Yong-pil Cho, Tae-won Kwon, Young-jun Choi, Eun-Kyung Lee, and Gyu-Jeong Noh.
• Departments of Anesthesiology and Pain Medicine;
• J. Cardiothorac. Vasc. Anesth. 2015 Oct 1; 29 (5): 1200-5.

ObjectivesTo explore the relationship between the maximal fractional decrease of regional cerebral oxygen saturation (rSO2) in neurologic derangement and the patency of the circle of Willis and contralateral carotid artery stenosis.DesignA prospective observational study.SettingsA tertiary-care university hospitalParticipantsThis study enrolled 307 patients undergoing carotid endarterectomy under regional anesthesia.InterventionsNo interventions.Measurements And Main ResultsMagnetic resonance angiography and carotid color-duplex ultrasound were performed, and the rSO2 was recorded. The relationship between the maximal fractional decrease of rSO2 from preclamp baseline against shunt insertion and patency of the circle of Willis was analyzed by a 2-way analysis of variance. Receiver operating characteristic analysis of the maximal fractional decrease of rSO2 also was performed to calculate the cut-off value for detecting neurologic derangement. In addition, probability of shunt insertion was estimated by logistic regression. Patency of the circle of Willis did not influence the maximal fractional decrease of rSO2. When both anterior and posterior circulations were nonpatent, the degree of contralateral carotid artery stenosis (Contra) was 54.7%±29.0% versus 40.7%±26.0% in patients with versus without shunting, respectively (p<0.05). The cut-off value of rSO2 for predicting shunt insertion was 25.8%, regardless of the patency of the circle of Willis. Probability of shunt insertion for nonpatent anterior circulation = exp(-2.02+0.02×Contra)/[1+exp(-2.02+0.02×Contra)].ConclusionsThe rSO2 can be used to predict shunt insertion, regardless of the patency of the circle of Willis. The probability of shunt insertion increased with increasing degree of contralateral carotid artery stenosis in the absence of anterior circulation in the circle of Willis.Copyright © 2015 Elsevier Inc. All rights reserved.

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