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- Denis Antoine, Andrew S Huhn, Eric C Strain, Gavin Turner, Jasmyne Jardot, Alexis S Hammond, and Kelly E Dunn.
- Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
- Am J Addict. 2021 Jan 1; 30 (1): 83-87.
Background And ObjectivesIndividuals exposed to fentanyl are at risk of precipitated withdrawal using typical buprenorphine/naloxone induction procedures.MethodsThis case series describes buprenorphine/naloxone inductions of four individuals who tested positive for fentanyl.ResultsBuprenorphine-precipitated withdrawal was observed in two individuals who completed a conventional buprenorphine/naloxone induction strategy. Two more individuals completed a revised buprenorphine/naloxone induction strategy that did not precipitate withdrawal.Discussion And ConclusionUsing multiple 2 mg doses of buprenorphine/naloxone in patients already in mild/moderate withdrawal improved outcomes.Scientific SignificancePersons who use illicit fentanyl might be less likely to experience precipitated withdrawal from this revised buprenorphine/naloxone induction strategy. (Am J Addict 2021;30:83-87).© 2020 American Academy of Addiction Psychiatry.
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