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Jornal de pediatria · Sep 2019
Prevalence and causes of congenital microcephaly in the absence of a Zika virus outbreak in southern Brazil.
- Silvani Herber, André A Silva, SanseverinoMaria Teresa VMTVSistema Nacional de Informação sobre Agentes Teratogênicos (SIAT), Porto Alegre, RS, Brazil; Hospital de Clínicas de Porto Alegre, Serviço de Genética Médica, Porto Alegre, RS, Brazil; Pontifícia Universidade Católica do Rio Gr, Luciana Friedrich, Tani M S Ranieri, Catia Favreto, Lucas R Fraga, Anna P Terra, Ida V D Schwartz, and Lavínia Schuler-Faccini.
- Universidade Federal do Rio Grande do Sul (UFRGS), Programa de Pós-graduação em Medicina em Ciências Médicas, Porto Alegre, RS, Brazil.
- J Pediatr (Rio J). 2019 Sep 1; 95 (5): 600-606.
ObjectiveThe aim of this study was to identify the causes of congenital microcephaly in Rio Grande do Sul, a state in southern Brazil, where no ZIKV outbreak was detected, from December 2015 to December 2016, which was the period when ZIKV infection was at its peak in northeast Brazil.MethodsThis was a cross-sectional study where all notifications of congenital microcephaly in the state of Rio Grande do Sul were included for analysis. Evaluation of cases followed the guidelines of the Brazilian Ministry of Health. Dysmorphological and neurological evaluations were performed by a specialized team, and genetic tests and neuroimaging were performed when clinically indicated. STORCH infections were diagnosed using standard tests. ZIKV infection was diagnosed through maternal serum RT-PCR and/or neuroimaging associated with clinical/epidemiological criteria.ResultsFrom 153744 registered live births in the study period, 148 cases were notified, but 90 (60.8%) of those were later excluded as "non-confirmed" microcephaly. In the 58 confirmed cases of microcephaly (prevalence = 3.8/10000 live births), congenital infections (syphilis, toxoplasmosis, cytomegalovirus, and ZIKV) constituted the predominant etiology (50.0%), followed by isolated CNS (15.5%), and genetic syndromes (10.3%). Congenital ZIKV syndrome (CZS) with typical phenotype was diagnosed in three cases (5.2% of all confirmed microcephaly cases or 10.4% of all congenital infections).ConclusionIn Rio Grande do Sul, where no outbreak of ZIKV infection was recorded, congenital infections were the leading cause of congenital microcephaly, and the attributable risk for CZS in the etiology of microcephaly was 5.2%.Copyright © 2018 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.
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