• Revue médicale suisse · Dec 2019

    Review

    [Direct oral anticoagulants in the treatment of cancer-associated thrombosis].

    • Laura Stebler-Fontaine, Anne Rossel, Christophe Marti, Marc Righini, and Helia Robert-Ebadi.
    • Service de médecine interne générale, HUG, 1211 Genève 14.
    • Rev Med Suisse. 2019 Dec 4; 15 (674): 2232-2235.

    AbstractThe use of direct oral anticoagulants (DOACs) has been largely -implemented in the management of venous thromboembolic disease in non-cancer patients. In cancer-associated thrombosis, low molecular weight heparins (LMWHs) and especially dalteparin have long been the reference standard therapy. Following the publication of two randomised trials comparing edoxaban and rivaroxaban to -dalteparin, DOACs now represent an alternative with an interesting efficacy and safety profile. Moreover, they offer the comfort of an oral administration and a lower cost. In patients with gastrointestinal or genitourinary cancers however, a higher bleeding risk has been shown with DOACs. LMWHs thus remain the treatment of choice in this group of patients.

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