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- Guillaume Moriceau, Romain Rivoirard, Benoîte Méry, Alexis Vallard, Cécile Pacaut, Jane-Chloé Trone, Sophie Espenel, Claire Bosacki, Jean-Philippe Jacquin, and Nicolas Magné.
- Chemotherapy. 2016 Jan 1; 61 (3): 122-6.
BackgroundTrabectedin plus pegylated liposomal doxorubicin (PLD) proved efficacious as second-line treatment for patients with recurrent ovarian cancer (ROC).MethodsWe report a single-center retrospective analysis of the efficacy and tolerance of trabectedin 1.1 mg/m2 every 3 weeks in a cohort of real-life ROC patients.ResultsFrom February 2012 to January 2014, 17 patients were treated with trabectedin alone or combined with PLD. Median age was 61 years (range: 48-78). Performance status was 0-1 in 16 patients (94%). Disease response rate was 53% and disease control rate was 76%. At the end of the follow-up, 8 patients (47%) were alive. Median overall survival was 17.6 months (95% CI 13.6 to not reached). Median progression-free survival was 6.7 months (95% CI 5.4-10.0). The most frequent grade 3-4 toxicities were neutropenia (n = 4, 24%) and nausea/vomiting (n = 4, 24%).ConclusionTrabectedin combined with PLD seems efficient in and well tolerated by real-life ROC patients.© 2016 S. Karger AG, Basel.
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